If the trials all go well we could be seeing a new topical agent coming to us sufferers soon.

Want to thank my dearest friend for keeping us in the loop of new things for Hyperhidosis, your a gem

NEW ANTIPERSPIRANT HYDROGEL WITH ACETYLCHOLINE BLOCKING
MECHANISM: FIRST CLINICAL REPORT
INTRODUCTION AND DESCRIPTION OF THE NEW ANTIPERSPIRANT GEL

A new antiperspirant hydrogel has been projected and discovered based on an innovative
mechanism of action consisting on acetylcholine release partial blocking. This biochemical
mechanism is the main involved in eccrine sweat glands secretion and is the main issue to solve in
the patients suffering of hyperhidrosis. Generally patients suffering of moderate to severe grade
hyperhidrosis undergo to botulinum toxin sessions properly to block acetylcholine release and so
reduce sweating for several months and furthermore apply day by day very high percentage of
Aluminum chloride topical products to reduce excessive sweating. Botulinum Toxin is very
effective because blocks specifically proteins which induce acetylcholine release and so reduce
dramatically eccrine glands secretion; unfortunately injection of botulinum toxin is a strict specialist
medical practice and is not free from side effects, contraindications, allergic events and so on. Not
all the patients could be enrolled to apply botulinum toxin and many times these patients, impatient
to solve their embarrassing condition, provide to buy this drug from not legal channels and accept
to be treated from not specialized and skilled people. Furthermore, in the cosmetic landscape,
there’s only aluminum chloride products capable to produce acceptable results, but they are not free
from side effects as adenitis and skin irritations if applied every day.
This new cosmetic approach to hyperhidrosis has the main purpose to give an important opportunity
to all the patients suffering of hyperhidrosis allowing them to treat this condition with the same
mechanism of action of botulinum toxin, but without inject anything and simply applying a pleasant
and light hydrogel in the axilla, face, hands and forehead.
This gel contains an association of natural substances capable to reduce acetylcholine release in the
proximity of eccrine glands reducing contextually their secretion, exactly as botulinum toxin, but in
a very natural and not invasive way.
PRELIMINARY CLINICAL REPORT
20 patients suffering of moderate to severe grade hyperhydrosis have been tested under the
supervision of specialized dermatologists in the San Gallicano Hospital Dermatology Department in
Rome.
These patients began application of this new gel (SNARE BLOCK), after two weeks from the
interruption of application of any other product for hyperhidrosis (aluminum chloride, long lasting
antiperspirant products etc.): they only applied short lasting deodorants and a common hygiene
protocol.
These patients were educated to apply SNARE BLOCK two times a day (morning and night) in the
affected area taking care to induce a complete absorption of the gel in the skin area involved with a
light massage. No other products for hyperhydrosis were applied with the exception of common
deodorants with no antiperspirant molecules inside.
These patients came back to the clinic once a week to compile a clinical report under supervision of
a dermatologist in charge to carry out the clinical evaluation.
The parameters considered were:
- Grade of subjective satisfaction;
- Grade of pleasantness of application;
- Indication of “sweat reduction grade” in a graduated scale;
- Fast working effect grade;
- Objective clinical examination;
At the end of the 4 weeks, 18 patients declared to be:
- quite satisfied to highly satisfied of the efficacy of the product indicating a grade of “sweat
reduction” ranging from 6 to 8 in a graduated scale ranging from 0 for no effects to 10 for complete
satisfaction. 1 patient interrupted after only 2 weeks declaring that the product didn’t work and
another one interrupted after 3 weeks with no explanations;
- in a scale ranging from 0 to 10 for the “sweat reduction” parameter grade 2 patients reported a
score of 8 (high grade of reduction), 13 patients reported a score of 7 (moderate-high grade of
reduction); 3 patients reported a score of 4-5 (moderate grade of reduction);
- 16 patients declared to be satisfied in terms of pleasantness in a scale reporting these parameters: 2
patients not satisfied (bad sensorial effect in the skin), 7 patients moderately satisfied (acceptable
sensorial effect, but not very nice), 9 very satisfied (very good skin effect and nice to apply);
- 18 patients declared a quite slow working effect onset: 7 patients declared to feel first working
effect in sweating only after 15 days from the first application and the best effect after 18-20 days.

Please join us in our friendly forum on more about this new and exciting product, feel free to leave your questions and comments.  

Original article here

Excessive Sweating Targeted by New Procedure

Everyone sweats but for some people the problem is so severe that they do not even want to leave their homes.

“It’s really emotional. It’s stressful,” said Briana Bernyk, who suffers from sweating so severely that she even skipped her high school prom.

“I didn’t want to go through the whole hassle of picking out a dress, so I blew it off,” she told “Good Morning America.”

Bernyk, 20, of Massachusetts, sweats so profusely under her armpits that she often has to throw shirts away after one use and wears layers to better protect herself. She also uses just one color in her wardrobe, black, in order to camouflage her ailment.

Miradry video – opens in new window

“From sweatshirts to fancy shirts, everything I have is black,” she said.

After trying topical solutions and even Botox to help lighten her sweating, Bernyk turned to what is being heralded as the latest fix for underarm sweating, a procedure known as miraDry.

“It’s not that they don’t sweat at all. They just sweat like a normal person,” said Dr. Michael Kaminer, a Boston-based cosmetic surgeon and the managing partner of SkinCare Physicians who performed the procedure on Bernyk, said of the results.

The nonsurgical procedure became available to patients in January after being approved by the Food and Drug Administration last year. While the patient’s armpit is placed under local anesthesia, microwave energy is used to melt the as many as 33,000 sweat glands in the armpits to stop the patient’s hyperhidrosis, the medical term for excessive sweating.

The company behind the procedure, Miramar Labs Inc. in Sunnyvale, Calif., says, on average, the overall volume of sweat is reduced by an average of 82 percent and lasts for nearly one year, according to its website.

Some medical experts say they are waiting for longer-term, independent data on the procedure, which can cost between $2,500 and $3,000 for two sessions and is not covered by insurance.

For Bernyk and other patients, the results speak for themselves.

“Now it’s just exciting to go out. I can wear what I want,” she said. “Before I was nervous about going out…uncomfortable and always in a cover up….[Now] I can hold them [my arms] on my hips and I can fix my hair in public.”

What does underarm sweat have to do with armpit acne?

Armpits.

Not a topic for everyday casual conversation. More often than not, this part of our bodies is a cause of insecurity—despite what the deodorant commercials show, most of us probably wouldn’t dare lift our underarms into the air so unselfconsciously particularly on a hot day in public. It’s also a source of inconvenience for women, as most of our fashion choices (sleeveless, cap sleeves, or long sleeves?) end up hinging on the state of our armpits. Of all the body parts we possess, this is one of those parts that tend to make us stressed out in an already-stressed out life.

Maintaining the hygiene of our underarms is as important as maintaining the hygiene for the rest of our bodies, as it is of the most sensitive parts. But many of us, in the hastiest of our lifestyles, usually focus on only two grooming aspects—keeping our underarms hair-free (especially for women), and keeping them from smelling. So we shave, spray, and use roll-ons with abandon, but fail to realize that improper care can cause skin trouble to our armpits.

Armpit acne is caused by a myriad of things. Certain fabrics and underarm products can irritate the skin. Improper shaving can result in “razor bumps”. But most commonly, armpit acne is caused, like the pimples on our faces, by the clogging of the pores with oil and bacteria. When left untreated, armpit acne can worsen and turn into serious skin problems.

Damp armpits don’t just increase the chances of body odor, but also traps bacteria. Combined with dirt from the air and the oils our bodies naturally possess, the skin becomes inflamed and becomes a pimple. These pimples can become painful, and are often filled with pus.

Solutions to sweating

Inability to control underarm sweating when you’ve developed one of these can lead to the pimple sticking around for a very long time, as the sweat continues to feed bacteria into the wound. Thus, the sweat glands in your underarm may end up become inflamed and infected. To prevent this, it is important to always keep our armpits clean and dry by using powders, or by regularly wiping sweat away. Many people would opt for antiperspirants, but this can end up worsening things as antiperspirants themselves clog pores to keep sweat from coming out. Badly clogged armpits can result in the inflammation of the sweat glands causing abscesses, which are infections caused by staph bacteria and require medical attention in order to heal.

Damp armpits also cause skin rashes on hot, humid days. Known as heat rashes, these are red, itchy rashes caused by the heat and the material of your clothing. Sometimes, the rashes develop whiteheads. On such days, you’ll want to wear light, airy fabrics that enable the breeze to pass through your clothes easily, eliminating sweat and odor constantly. You also want to avoid shaving, as improper shaving can cause hair follicles to be trapped under the skin causing irritation.

Armpit acne can be treated by bathing thoroughly and regularly, using creams and soaps containing salicylic acid or benzoyl peroxide that dry out pimples and pus. It is important to dry your underarms properly after showering to prevent dampness. Pimple creams created for facial use can be used safely on underarms. As these dry out even unaffected skin, always use a non-greasy moisturizing lotion afterwards. Cutting down on greasy food is also advisable in order to prevent overproduction of oil in our systems. When using deodorants, it’s best to go for a hypoallergenic one without fragrances that can further irritate the skin. When armpit acne is severe, though, do not hesitate to approach your dermatologist, who can provide prescription medicines suiting your current needs.

We don’t have to get to that point, though. Maintaining proper hygiene can keep us from developing armpit acne in the first place. Other additional tips for proper underarm care include exfoliating occasionally, using light scrubs in order to remove dead skin cells and lingering dirt. A regular routine of underarm hair removal through methods like waxing, plucking, or using depilatory creams is also advised in order to prevent BO. With a little effort and dedication, your underarms don’t have to be your enemy anymore.

Author bio:
Beth Coleman is a Gym Junkie, a Vegan, she never eats meet and the likes. She also has a passion in cooking and formulating vegan recipes.Follow her adventures on her Twitter.

I posted this a week or so ago and it still stands, volunteers are needed for the below study – a new treatment for axillary hyperhidrosis. Do look into it to see if you may be eligible, it may just be an answer to your sweating. Do remember to ask questions, for example Compensatory Sweating.

If this is for you and you have the procedure done, please let us know your story, as ever, this will help other people.

Don’t forget, everything you say to us is anonymous automatically, unless you give express permission for us to use your name.

______________________________________

Research Study Using a Radiofrequency (RF) Device to Treat Excessive Underarm Sweating

Volunteers are needed to participate in a research study that utilizes a non-invasive radiofrequency (RF) device to treat excessive underarm sweating.

Eligible participants must be male or female between the ages of 20 and 65 years of age, must be in good health, and must not be pregnant.

The Study consists of one to two treatments and three additional follow-up visits and lasts approximately 7 months.

Treatment will be provided at no charge.

For more information on the Study,
please contact Dennell Krzyzanowski at (510) 780-4680

Research Study Using a Radiofrequency (RF) Device to Treat Excessive Underarm Sweating

Volunteers are needed to participate in a research study that utilizes a non-invasive radiofrequency (RF) device to treat excessive underarm sweating.

Eligible participants must be male or female between the ages of 20 and 65 years of age, must be in good health, and must not be pregnant.

The Study consists of one to two treatments and three additional follow-up visits and lasts approximately 7 months.

Treatment will be provided at no charge.

For more information on the Study,
please contact Dennell Krzyzanowski at (510) 780-4680.

Laulas shirts

As just about everyone on www.verysweatybetty.com knows, I’ve suffered with Hyperhidrosis all my life.  That’s 43 years, in case you were wondering.

Hyperhidrosis is a non-discriminatory skin disease which affects a significant proportion of people across the world.  It is estimated to affect around 3% of the population – although if you’re like I was, thinking it was ‘just me’ – then you don’t bother to see your doctor about it.  That means the 3% figure is nothing more than a minimum guestimate.

There’s sadly no cure for Hyperhidrosis.  Not yet, anyway.  Anyone or any website who claims differently is not worth bothering with.  These sites exist for one reason only, that’s to make money from people like us, people who are desperate enough part with a lot of money for drugs, ebooks, surgical procedures, various products that claim to cure us and end our suffering.  Trust me, if there was a cure then I’d be out enjoying life instead of shying away from hot and humid weather and you wouldn’t be reading this review.  Instead, I choose to spend my time helping people come to terms with – and learn to cope with their excessive sweating.  For free.  And no, I don’t get paid.  This is a labour of love!

From time to time, verysweatybetty.com is lucky enough to trial different products.  As we would do practically anything to help our members, we take the hits for you.  There’s nothing worse than spending lots of money on something that claims to work but at the end of the day, makes little or no impact on your symptoms.  When we get to try products, we report back – honestly – and that helps you to make a more informed choice.

A product I’ve been trying for the last few weeks is a Laulas tee-shirt from www.sweat-help.com.  Gerhard, who also suffers from Hyperhidrosis, has invented and perfected the Laulas over many years and it works so well they actually don’t have a need to sell any other products.

This is the production information on their website – www.sweat-help.com:

The Laulas tee-shirt is made by a traditional Swiss Company
The fabric is 100% cotton with the Oekotex standard 100 seal (tested for harmful materials, produced in an environment friendly establishment)
100% cotton yarn of “Swiss cotton ring” (women’s shirt with 5% Lycra)

My verdict – the Laulas more than lives up to it’s high production values.  It’s the softest, lightest, silkiest feeling cotton tee-shirt I’ve ever felt.  It’s nothing like the thick, stiff cotton garments that are more commonplace – there really is no comparison between Laulas fabric and just about any other tee-shirt brand available.  On that alone, you will be thrilled with your purchase.

I have taken the next part direct from Laulas’ website (http://www.sweat-help.com/help)

Naturally sweating, let it flow, don’t prevent it!
I have been looking for possibilities to let my sweat just flow but haven’t found anything.
Until my t-shirt! 2003 – my first prototype was ready and a new life began.
Being able to wear blue shirts, reach up in the air, being able to just take off the jacket when it’s warm in the room was wonderful.
It took a while until everything was ready …

But now it’s here!

The functional shirt is for women and men

* The shirt that makes it possible to just let the axillary sweat flow and nobody can see it.
* The shirt that gives you new freedom.
* The shirt that takes away the fear of extreme sweating and reduces the visibility of sweat.
* It only takes you two minutes a day.

The result

* No changes to your body, neither from the inside nor from the outside
* No white lines on your shirts – No discolored shirts anymore
* No fear of lifting the arms.
* No pitiful and disgusted looks anymore.

Letting your sweat flow makes a lot of sense.  Bear with me, I’ll explain as best I can.  When you sweat, it’s for a reason – it’s to cool you down and prevent us from the dangers of overheating.  You will only stop sweating until your body is at the right temperature.  If you blocked every single one of your pores, then you wouldn’t sweat.  However, that would completely go against the whole reason for us having the ability to sweat in the first place.  If you blocked half of your pores, you would still sweat from the unblocked pores – but the likelihood is that you’d sweat more and for longer.  Your body would be working much harder to cool you down.  This is borne out by the vast majority of people who have had surgery for their sweating – ETS (Endoscopic Thoracic Sympathectomy), which blocks off sweating from above the nipple line, instead delivers unacceptably high levels of sweat from below the nipple line.  This is called Compensatory Sweating (CS).  Letting your sweat flow is natural and not a danger to your health.  Until we have a cure, the only thing you can really do for it is to manage it the best way you can.

The Laulas concentrates a lot of it’s energies towards helping Axillar Hyperhidrosis – in other words, sweaty armpits.  I’m from London, originally, and anybody who has ever travelled on the underground train network will have lost count of all the enormous patches of sweat appearing from their own underarms and those of their fellow passengers.  The Laulas is there to actively catch this sweat.  It also has discrete little pockets you can pad with absorbent paper (Tempo, Plenty etc) which will help even the heaviest sweater.  I’m an average underarm sweater and didn’t need to use the extra padding.

My Laulas tee-shirt arrived at just the right time.  We have recently had builders in to refit our kitchen and fit both bedrooms, that involved a lot of sweat-inducing work as we had to move everything out of these rooms so they could have access.  This also happened to be during the hottest few weeks of the (UK) summer.

I was really pleased with the hard-working efficacy of the tee-shirt.  For a garment to be so soft, you just can’t possibly understand just how mighty it’s hidden power is until you’ve tried it for yourself.  As it’s 100% cotton, it absorbs well and dries fast.  No matter how much I sweated, it caught it and helped it to evaporate.  I knew how bad I was sweating because the rest of my body was drenched – I’m an extreme sweater and sweat from my scalp to my feet.  The only area the sweat was actively contained and hidden was on my upper body.  Although the Laulas places a lot of focus on the underarm area, it still helps with other problem areas of sweating.  My back is one of the areas I sweat the most and usually my tee-shirts end up wringing wet – the Laulas even helped with that, no break-through back-sweat.

The Laulas is simple, effective and very comfortable.  No matter whether you’re male, female, young or old, there is a Laulas for everyone – I can’t recommend them highly enough.

Beverly Stacey
www.verysweatybetty.com

Useful links (open in new windows)  Laulas website and Laulas video

Hyperhidrosis, or excessive sweating, is a skin disease which produces a lot of unhappiness.  It is estimated by the medical profession that 2-3% of people all around the world suffer from excessive sweating.  Non-medically speaking, the figure could easily be far, far higher.  In our experience, many people only find out they have Hyperhidrosis because they stumble across the name of it by accident.  Many people don’t want to bother their doctor because they think it’s ‘just them’.  There are many reasons why people can go throughout life and never mention it to anybody. Read the rest of this entry »